Santification is a new end-game crafting system due to be introduced in Patch 2.5.0 scheduled to be released by the end of 2025.
This is a final roll of the dice and is a one-time, irreversible enchantment. Once the item has been sanctified, it is locked so the item can't be Tempered, Masterworked or Enchanted. You can however, change socketables.
Sanctifying will add one rare transformative bonues but if you're lucky it will add an additional Legendary, Unique or Mythic Power.
To Sanctify you'll need to spend Heavenly Sigils, which you can earn by defeating Bartok, Astaroth or the Exalted Lair Boss Belial. There is a small chance of drops from Belial Ambush, Pit Belial, Elites and Nightmare bosses on Torment difficulty and above.
Heavenly Sigils are also used to teleport to the Heavenly Forge where the Sanctification takes place.
