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Neo Rune

From Diablo 4 Wiki

Runes allow you to slot two runes into certain items to create a Runeword that triggers effects including class skills

  • Runes can be traded.
  • Runes are stackable in the socketable inventory tab.
  • A maximum of 2 Runewords can be equipped at once.
  • The same Rune cannot be equipped twice.
  • Runes can be used in crafting.

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Neo Rune

Type: Rare
Gain: 200 Offering
Ritual Rune: Avoid health damage while fighting for 2 seconds. (Resets if Invulnerable.)


Changes to Neo Rune

Patch 2.0.5, November 19, 2024

  • Is no longer blocked by invulnerability.
  • The Tooltip now specifically states that you must take health damage to stop this effect.

Patch 2.0.1, October 8 2024