I'm 10 hours into second and what seems to be the best farming set I've ever done so far. What I changed is increased Blizzard damage by around 3k and doing slightly more focus on checking drops instead of immediately going back to the waypoint. Result is more items farmed per time invested. Comparing to my best set ever done from RFL 2017, now I'm supposed to farm 50-100 items more in jewels/charms/rings (individually) while being half second slower than before and possibly 1 second slower than I could be. So, overall 200 runs total less, but what seems to be ~20% more items farmed per item type with exception of rare rings where difference is less.
So, fastest possible runs or a better farm? 200-300 runs less means absolutely nothing for winning odds since big boys drop at average once every ~1950 or whatever runs. You are either lucky to find them or you aren't.
The point I'm trying to make is this. Once sorc reaches sub 20 seconds running, it's pretty irrelephant whether she is 16s or 19s runner, their winning odds are pretty much the same, it's better to focus on farming instead. Same as for a barb. It is hard to maintain sub 30s running without skipping drops, while difference between 32s barb and say 27s barb is nearly non-existent when it comes to farming runes. I'm convinced that my MF sorc variant I did the first set is best possible approach to Travincal running. Not the fastest, but best farming possible. As for barb, he doesn't really have MF variation in that way, or it isn't possible to make it as focused as with sorc.
I think there is no need to be super focused on runtimes. Rather, focus on farming is better and more profitable way of looking at running in general, not just Travincal.