@Grisu IMO it depends on how screwed you get from damnations. Some classes/builds have bad options, others are fine using some other skill until normal cow king without much trouble. Also of course there are respecs as well so saving Normal Den of Evil is another solution. But I have future plans for my character and in such cases I usually try to use only one respec at most during playthroughs. Anyway luckily I didn’t have such problems.