Silence

Silence, made from Dol + Eld + Hel + Ist + Tir + Vex, in that order. This is a crossbow, but this recipe works in all types of weapons. Possible in v1.08 and above.

Incredible list of mods here, but with 6 runes, and Dol and Vex both very rare, you'd expect quite a lot, and you get it. Enormous resistance, +2 to all skills, huge damage, mana leech, etc. The only bad part is the hit causes monster to flee, but it's only 25%, so for all the rest you could probably get over that. And the Hit Blinds Target will cancel that out most of the time anyway.

Runeword	Stats	Comments	Active In
			v1.11+	v1.10	v1.09
Silence DolEldHelIstTirVex Dol (14) + Eld (2) + Hel (15) + Ist (24) + Tir (3) + Vex (26) All Weapons. Clvl Required: 55	+200% Enhanced Damage 175% Damage vs. Undead +50 to Attack Rating Against Undead 11% Mana Steal Hit Blinds Target (20) Faster Hit Recovery +2 to All Skills All Resistances +75 20% Increased Attack Speed +2 to Mana After Each Kill Hit Causes Monster to Flee 25% Requirements -20% 30% Better Magic Find	See it here.	Yes	Yes	Yes