Horadric Cube Rune Upgrades

3 El Runes --> 1 Eld Rune
3 Eld Runes --> 1 Tir Rune
3 Tir Runes --> 1 Nef Rune
3 Nef Runes --> 1 Eth Rune
3 Eth Runes --> 1 Ith Rune
3 Ith Runes --> 1 Tal Rune
3 Tal Runes --> 1 Ral Rune
3 Ral Runes --> 1 Ort Rune
3 Ort Runes --> 1 Thul Rune
3 Thul Runes + 1 Chipped Topaz --> 1 Amn Rune
3 Amn Runes + 1 Chipped Amethyst --> 1 Sol Rune
3 Sol Runes + 1 Chipped Sapphire --> 1 Shael Rune
3 Shael Runes + 1 Chipped Ruby --> 1 Dol Rune

Higher level runes can also be upgraded, but only in v1.10 and later and only by single-player, realm, or ladder characters.

3 Dol Runes + 1 Chipped Emerald --> 1 Hel Rune
3 Hel Runes + 1 Chipped Diamond --> 1 Io Rune
3 Io Runes + 1 Flawed Topaz --> 1 Lum Rune
3 Lum Runes + 1 Flawed Amethyst --> 1 Ko Rune
3 Ko Runes + 1 Flawed Sapphire --> 1 Fal Rune
3 Fal Runes + 1 Flawed Ruby --> 1 Lem Rune
3 Lem Runes + 1 Flawed Emerald --> 1 Pul Rune
2 Pul Runes + 1 Flawed Diamond --> 1 Um Rune
2 Um Runes + 1 Topaz --> Mal Rune
2 Mal Runes + 1 Amethyst --> Ist Rune
2 Ist Runes + 1 Sapphire --> Gul Rune
2 Gul Runes + 1 Ruby --> Vex Rune
2 Vex Runes + 1 Emerald --> Ohm Rune
2 Ohm Runes + 1 Diamond --> Lo Rune
2 Lo Runes + 1 Flawless Topaz --> Sur Rune
2 Sur Runes + 1 Flawless Amethyst --> Ber Rune
2 Ber Runes + 1 Flawless Sapphire --> Jah Rune
2 Jah Runes + 1 Flawless Ruby --> Cham Rune
2 Cham Runes + 1 Flawless Emerald --> Zod Rune