It will disappear. Uber portals are just like the cow portal, i.e. game-specific.
Also: take care not to create all the portals in the same place (only one of them will be accessible then!). It's a common mistake when first making them.
It's best to wait 5 minutes for the game to perm, then open all 3 portals but moving in between so they're not on top of each other.
The reason why you should open all 3 at the same time is that they will all be different portals. This way you get all the organs;
if you opened each portal in a separate game, you could have 3 Izual portals, for example, and would then have to hassle around selling organs.
As a final tip, make one of the portals near Larzuk so you can shop for nice armors and shields for a while. I've been trying for ages to get a Jeweler's of the Whale from Anya; I don't have the keys or an Uber-capable char on Nl yet so I can't make the portal near Larzuk.