Actually I think a DTalon/BF/DS Sin is one of the best candidates for a massive PDR/MDR build. And when I say massive, I mean in the realms of 100-140 PDR / 75-90 MDR. This is due to the relative soft equipment restrictions, as typically you only need a good weapon and a good pair of boots to be effective with such a build.
Note: %DR on Stormshield, Shako, Verdungo's etc is much less important here, as it is only applied after PDR. This is basically the same as Resists (%DR can be considered as Physical Resistance), which means that if you have oodles of MDR, you can pretty much walk around with poor Resists and still survive.
How many equipment slots you can devote to PDR/MDR depends on how many desirable mods you can fit on your weapon, boots & gloves (I will also allow gloves, since there's not too much in terms of damage reduction potential there). If out of those 3 pieces of equipment you can put together CB, OW, elemental damage, CTC effects, leech, IAS (dependent on your weapon type), you can be an immortal pillar of mass destruction.
Some of the 'dream' equipment for this set up (brackets indicate sockets):
Helm
Artisan's / Jeweler's Circlet of Life Everlasting (Sol + Sol + Sol)
Shadow Circlet of Life Everlasting - you have to hope that you get lucky at Larzuk's to socket some Sol runes
Vampire Gaze (Sol): if you can get PDR elsewhere, the healthy MDR & leech makes this an awesome headpiece to wear.
Armor
Gladiator's Bane (Sol) / Iron Pelt (Sol) - Gladiator's Bane would also give you CBF, freeing up a Ring slot
Jeweler's XXX of Amicae (Sol + Sol + Sol + Sol)
Ring
Dwarf Star x 2: Fire absorb, good MDR, life - nuff said
Amulet
Shadow Amulet of Life Everlasting
Shield
Jeweler's Monarch of Amicae (Sol + Sol + Sol + Sol) - Monarch is the lightest 4 socket shield
Gerke's Sanctuary (Sol)
Belt
String of Ears
For the above listed items, choice will obviously come down to what you have available. If that is not a problem, then balancing amounts of PDR & MDR may depend on which type of damage you find more threatening to yourself.
Now if you already have enough PDR but a little lacking in MDR, you can of course socket some Mals instead of Sols. But whether anybody has that many Mal runes sitting useless on a mule remains to be seen.
My current set up of Stormlash, Gore Rider Myrmidon Greaves and Dracul's Grasp means that I've covered basically everything I need to be an efficient killer, meaning all other slots can be used for damage reduction. The only thing missing, mana leech, is readily available on the Vampire Gaze too. The speed of the Scourge and the IAS already present means I'm already at the 3 frame follow up for Dragon Talon without Burst of Speed.
Note: if there's no obvious socket option in the weapon, you can always go for a Perfect Skull. Its 3% mana leech is plenty for a cheap skill like Dragon Talon.
This sort of build has various forms of damage to deal with immunities, good crowd killer in DS, tank in the Shadow Warrior (I use mine to cast CoS & DS), CoS/MB for crowd control, massive damage vs single targets and BF as a ranged option & when IM is around - ON TOP of near item based immortality.
Expensive & specific to make, yes, but you'll have one hell of a PvM build to brag about.
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